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Achieving potent pain alleviation through cannabis use

Ancient cultures have long utilized cannabis for medicinal purposes, particularly for pain alleviation. With the ineffectiveness of opioids becoming evident, there's a resurgence of interest in cannabis that could lead to enhanced pain management solutions.

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2025 June 6 . 10:58 PM

2 min read

Ancient medicinal use of marijuana persists, particularly for managing pain. The ineffectiveness of... — Ancient medicinal use of marijuana persists, particularly for managing pain. The ineffectiveness of prescription opioids could rekindle exploration of marijuana, potentially leading to innovative and enhanced pain relief solutions.

Achieving potent pain alleviation through cannabis use

Chronic pain can be debilitating, and traditional solutions like opioids are addictive and come with unwanted side effects. Thankfully, researchers are exploring new alternatives, even finding one that seems to bypass the brain entirely.

This potential game-changer is a cannabinoid molecule, extracted from the cannabis plant. Unlike its mind-altering counterpart, this compound is modified to only bind to pain-sensing nerve cells outside the brain, promising pain relief without the usual high or addiction risks of cannabis or opioids.

The researchers, hailing from Washington University School of Medicine and Stanford University, tested their innovative compound in mouse models of nerve-injury pain and migraine headaches. Encouragingly, their injections halved touch hypersensitivity in both models, demonstrating significant pain relief.

Senior author Dr. Susruta Majumdar from WashU Medicine summarizes it best, "Our modified compound attaches to pain-reducing receptors in the body, but by design, it can't reach the brain. This means the compound avoids psychoactive side effects such as mood changes and isn't addictive because it doesn't act on the brain's reward center."

If you're grappling with chronic pain and seeking alternatives, you may want to consider cannabis itself. Studies demonstrate that its primary compounds - THC and CBD - provide pain relief. In fact, cannabis relieved pain in 95.9% of cancer sufferers who tried it!

If you're hesitant about the cannabis high, opt for CBD instead. CBD offers numerous anti-inflammatory and pain-relieving properties without the mind-altering effects. Just make sure you select a high-quality CBD supplement with accurate CBD content.

While a specific modified synthetic cannabinoid compound like the one described above isn't commercially available yet, alternative products and compounds, such as CONOCB2 and Win 55212-2, present promising avenues for pain relief without the risks associated with traditional opioids and cannabis. Keep an eye on future breakthroughs in this exciting area of research!

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Sources:- Compound harnesses cannabis' pain-relieving properties without side effects - EurekAlert!- Further insights on synthetic cannabinoids, CONOCB2, and non-THC/CBD solutions can be found by exploring various resources such as academic journals, research publications, and reputable news outlets related to pharmaceuticals, pain management, and cannabis research.

This modified synthetic cannabinoid compound, currently not commercially available, shows significant potential for providing pain relief without the psychoactive side effects associated with traditional cannabis or opioids, as it specifically targets pain-sensing nerve cells outside the brain.
As an alternative to traditional opioids and cannabis, CBD offers numerous anti-inflammatory and pain-relieving properties without the mind-altering effects, making it a suitable choice for those seeking relief without the high.