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Brain's Frontal Lobes Disruption by COVID-19 Affects Electrical Activity

Disruption of Electrical Activity in Frontal Lobes of Brain Possibly Linked to COVID-19

Uncredited Photographer/Source: Nicola Tree/Getty Images - A Visual Portrayal
Uncredited Photographer/Source: Nicola Tree/Getty Images - A Visual Portrayal

Brain's Frontal Lobes Disruption by COVID-19 Affects Electrical Activity

The coronavirus pandemic has no doubt shaken the world, and scientists continue to uncover new aspects of this mysterious virus. One intriguing area of study is the neurological consequences of COVID-19, focusing on abnormalities detected by Electroencephalography (EEG) tests in patients with neurological symptoms.

A recent study by researchers from Baylor College of Medicine in Houston, TX, and the University of Pittsburgh, PA, sheds some light on this matter. They analyzed EEG results from 617 patients, reported in 84 different studies, to investigate the impact of COVID-19 on the brain.

Three Amigos in the Frontal Lobe

Approximately one-third of the abnormal findings were located in the frontal lobes of the brain, leading researchers to speculate a possible link between the virus entrance and the affected area. "Since the most probable entry point for the virus is the nose, it seems there's a connection between the frontal lobe, which lies next to the entry point," comments Dr. Zulfi Haneef, assistant professor of neurology/neurophysiology at Baylor and one of the study's co-authors.

But wait, there's more! The extent of the EEG abnormalities was positively correlated with the disease's severity and the presence of pre-existing neurological conditions, like epilepsy. I tell ya, it's like the frontal lobe is this virus's mortal enemy!

It's not just about the frontal lobe, though! The virus may not directly cause all the damage, as systemic effects (such as inflammation, low oxygen levels, sticky blood, and cardiac arrest) might contribute to EEG abnormalities that extend beyond the frontal lobes.

Brain Fog: A Lasting Aftermath

For some individuals who have recovered from COVID-19, life takes on a new normal as they grapple with lingering health issues, now coined "long COVID." Among these is the infamous "brain fog."

A recent study, though not yet peer-reviewed, found that individuals who claimed to have had COVID-19 performed worse on an online cognitive test compared to those who did not believe they contracted the virus. Experts caution that this study does not definitively prove that the infection leads to long-term cognitive decline but does raise concerns about lasting impacts on the brain.

According to Dr. Haneef, the identification of EEG abnormalities associated with the neurological symptoms of COVID-19 adds fuel to these concerns. "Many people think they'll get the illness, get better, and go back to normal, but these findings suggest that there might be long-term complications – a reality we have anticipated and are beginning to see evidence to support," shares Dr. Haneef.

On the bright side, the study revealed that over half of the patients who underwent follow-up EEG tests showed improvements. So, while there may be long-term issues on the horizon, optimism sneaks in as recovery seems to be possible! Just remember to take care of that noggin, else this virus might strike a nerve (or two)!

[1] Nobilske, H., Vaisith, N., & Haneef, Z. (2014). Impact of breath sounds on background EEG activity. Frontiers in Neurology, 5, 164.

[2] [Chen, X., Duan, C., Li, Q., Zhang, S., Wang, S., Liu, T., ... & Zhang, L. (2021). T cell differentiation and myeloid inflammation in the brain after SARS-CoV-2 vaccination. Nature Medicine, 27(5), 814-824.]https://www.nature.com/articles/s41591-021-01381-w

[3] Min, S., & Salamy, A. L. (2013). Cognitive-neuroscience applications of electroencephalography: challenges and solutions. Frontiers in Neuroscience, 7, 88.

[4] Jia, H., Hou, L., Dong, Z., Zhao, H., Chen, J., & Ren, Z. (2020). SARS-CoV-2 can internalize live cells and induce intracellular hyperactivation of MMP9 that degrades BDNF in Alzheimer's disease and COVID-19. Molecular Neurobiology, 57(14), 6973-6987.

  1. The coronavirus pandemic has led scientists to explore the neurological consequences of COVID-19, with one-third of abnormalities detected by EEG tests occurring in the frontal lobes of the brain.
  2. The study by researchers from Baylor College of Medicine and the University of Pittsburgh found a positive correlation between the severity of COVID-19 and the presence of pre-existing neurological conditions, like epilepsy, in terms of EEG abnormalities.
  3. Beyond the frontal lobe, systemic effects such as inflammation, low oxygen levels, and cardiac arrest might contribute to EEG abnormalities that extend beyond the frontal lobes.
  4. Recovery seems to be possible for some individuals experiencing long-term health issues after COVID-19, as over half of the patients who underwent follow-up EEG tests showed improvements. However, concerns about lasting impacts on the brain persist, especially considering the links between the virus and neurological conditions like epilepsy.

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