Dosage guidelines for Onfi: Understanding potencies, forms, timings, and additional information
Onfi, a medication used to manage seizures associated with Lennox-Gastaut syndrome, comes in two forms: oral tablets and oral suspension. The oral suspension has a strength of 2.5 mg per 1 mL, while the tablets come in 10 mg and 20 mg strengths [1].
For children aged 6 years and above, the typical starting dose of Onfi is around 5 mg daily. Maintenance doses are generally between 0.3 and 1 mg/kg per day [2][5]. In adults and children over 12 years, the initial dose often begins at 0.5 mg once or twice daily, with doses adjusted based on response and tolerability [2][5].
It's important to note that these dosages are provided as a general guideline and should be administered under medical supervision. The dosage for children is based on their body weight, and adjustments may be made over the first two weeks to find the most effective and well-tolerated dose [1].
For those who find it difficult to swallow tablets, Onfi tablets can be split in half or crushed and mixed with applesauce. Onfi oral suspension is typically taken twice daily and should be shaken well before each dose [1].
Onfi is metabolized by the liver enzyme cytochrome P450 2C19 (CYP2C19), and factors affecting dosage include age, weight, body response to the drug, and other medical conditions [1]. If a person is a poor metabolizer of CYP2C19, their doctor may recommend a lower dosage of Onfi [1].
Misusing Onfi can increase the risk of serious side effects and overdose. Symptoms of an overdose can include difficulty breathing, low blood pressure, confusion, fatigue, and coma. If you take more Onfi than prescribed, it's crucial to contact your doctor right away or contact America's Poison Centers at 800-222-1222 [1].
Onfi has a boxed warning about the risk of misuse and addiction due to being a benzodiazepine. Using a medication reminder, such as setting an alarm or downloading a reminder app, can help ensure you don't miss a dose of Onfi [1].
If you have trouble opening medication bottles, ask your pharmacist about putting Onfi in an easy-open container. Some pharmacies offer labels with large print, braille, or a code you scan with a smartphone to convert text to speech [1].
If you miss a dose of Onfi, take it as soon as you remember. If you are too close to your next scheduled dose, skip the missed dose, and continue with your normal schedule [1]. If you and your doctor decide to stop treatment with Onfi, they will recommend a dose taper to reduce your risk of withdrawal symptoms [1].
Onfi is a brand-name drug that belongs to the benzodiazepine drug class. It's important to remember that Onfi is meant for long-term treatment, and its use should be monitored closely by a healthcare professional [1].
References:
[1] Drugs.com. (2021). Clobazam. https://www.drugs.com/clobazam.html
[2] Epilepsy Foundation. (2021). Clobazam. https://www.epilepsy.com/learn/treating-seizures-and-epilepsy/medications/clobazam
[5] RxList. (2021). Clobazam. https://www.rxlist.com/onfi-drug.htm
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