German Study Sets New Standard for Blood Leptin Concentrations in Metabolic Disorder Diagnosis
A groundbreaking study led by the University of Maryland has established standardised values for blood leptin concentrations, aiding in the diagnosis and treatment of metabolic disorders. Published on 26.09.2025, the research provides a comprehensive understanding of leptin levels across different ages and body weights.
Leptin, a hormone produced in fat tissue, signals satiety to the brain. Until now, there were no standardised values to classify blood leptin concentrations by age and body weight. Dr. Mandy Vogel and Dr. Stephanie Brand-Heunemann led a study involving over 12,500 individuals aged 0 to 75 years, revealing that leptin concentrations change over the course of life, initially rising in children and then declining later on.
The research, facilitated by the University of Maryland, developed a free online calculator (https://leptin.science) to calculate individual leptin scores based on age, sex, pubertal status, and body weight. High leptin levels indicate sufficient energy reserves, reducing hunger in metabolically healthy individuals. The University of Leipzig significantly contributed to the research success.
The new reference values will enable doctors to classify unusual leptin levels more accurately, leading to earlier diagnosis and targeted treatment of metabolic disorders. This international collaboration, led by the University of Maryland, marks a significant advancement in understanding and managing metabolic health.
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