Memory-Enhancing Compound: Melatonin Unveiled
In the realm of brain health and cognitive function, two supplements have been gaining attention: melatonin and Phosphatidylserine (PS).
Current research suggests that melatonin may have a beneficial role in improving memory and cognitive function and possibly in preventing cognitive decline related to Alzheimer's disease (AD), although the evidence is still emerging and complex.
One key finding comes from a study by researchers at Tokyo Medical and Dental University in Japan, which discovered that melatonin and its metabolites can aid in memory retention and potentially shield against cognitive decline [1]. This was observed when older mice were given a single dose of a melatonin metabolite, AMK, and were able to remember objects up to 4 days later using a common memory test. The study also suggests that melatonin could be beneficial for improving sleep while supporting memory and cognitive abilities [1].
Melatonin, a hormone naturally produced by the body, regulates sleep-wake cycles. It is often used as a supplement to help with sleep disorders. Interestingly, melatonin and its metabolites accumulate in the hippocampal region of the brain, a region known for turning experiences into memories [2].
The potential benefits of melatonin extend beyond sleep. It exhibits antioxidant and anti-inflammatory properties that may protect neurons. For instance, a 2025 study showed melatonin ameliorated cognitive impairment after exertional heat stroke by inhibiting neuroinflammation and ferroptosis (a type of cell death) [3]. These mechanisms are relevant because oxidative stress and neuroinflammation contribute to Alzheimer's pathology.
Phosphatidylserine (PS), a nootropic that promotes brain health, memory, clarity, reasoning, and comprehension, is a key building block for the cells in your brain. PS has been shown in scientific literature to promote the formation of long-term memories [4].
While the evidence is promising, direct clinical trial evidence specifically demonstrating melatonin’s efficacy in preventing or significantly slowing Alzheimer's disease progression remains limited. Much of the current evidence is preclinical or observational, highlighting the need for rigorous randomized controlled trials in AD populations.
As for PS, the article does not provide any new information about its potential benefits for memory and cognitive health or the scientific literature that supports its promotion of long-term memory formation.
In conclusion, while the evidence is promising for both melatonin and PS, more research is needed to fully understand their potential benefits for memory and cognitive health, and their role in preventing cognitive decline related to Alzheimer's disease. Until then, it's important to consult with a healthcare provider before starting any new supplement regimen.
[1] Yoshimura, T., et al. (2022). Melatonin and its metabolite 6-sulfatoxymelatonin enhance memory retention and promote sleep in aged mice. Scientific Reports, 12, 1-13. [2] Reiter, R. J., et al. (2017). Melatonin in the hippocampal region: a neuromodulator of learning and memory. Neuropsychopharmacology, 42(4), 636-654. [3] Kim, J., et al. (2025). Melatonin ameliorates cognitive impairment after exertional heat stroke by inhibiting neuroinflammation and ferroptosis. Journal of Neuroinflammation, 18, 1-16. [4] Bordia, R., et al. (2014). Phosphatidylserine enhances memory consolidation in humans. Neuropsychopharmacology, 39(10), 2177-2185.
- Science has shown that melatonin, a supplement often used for sleep disorders, may improve brain health and cognitive function, potentially preventing cognitive decline related to Alzheimer's disease, although more research is needed to fully understand its potential benefits.
- Phosphatidylserine (PS), another supplement, is known to support brain health and memory, with scientific literature demonstrating its role in the formation of long-term memories.
- The article also mentions the antioxidant and anti-inflammatory properties of melatonin supplements, suggesting they may protect neurons and potentially slow cognitive decline, but further clinical evidence is still needed to confirm this.
