New Hope Against Salmonella: Scientists Discover C26
Scientists from the University of Tübingen and the German Center for Infection Research have made a significant breakthrough in the fight against salmonella infections. Their discovery, published in the journal Science Advances, introduces a substance called C26 that targets the pathogen's invasion mechanisms, offering a promising new approach to treatment.
The team's research, detailed in the article 'Discovery of synthetic small molecules targeting the central regulator of Salmonella pathogenicity', focuses on a substance that inhibits the signal chains of pathogens during cell invasion. Unlike traditional antibiotics, C26 acts early by specifically disrupting the infection mechanisms of the salmonella bacteria, making resistance less likely.
C26 targets a crucial regulator in salmonella's invasion process, HilD. By interfering with HilD, C26 prevents the bacteria from injecting effector proteins into cells of the stomach and intestinal tissue. This innovative strategy offers a new hope in the battle against salmonella infections, which affect both humans and animals.
The discovery of C26 by the University of Tübingen and the German Center for Infection Research opens up exciting possibilities for the development of new medications to treat salmonella infections. With its unique mode of action, C26 could potentially provide a powerful tool in the fight against these harmful pathogens, offering a much-needed alternative to traditional antibiotics.
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