Online Course Focuses on Single-Cell Analysis in Cancer Biology

Online Course Focuses on Single-Cell Analysis in Cancer Biology

A new webinar series titled "Single-Cell for Cancer Biology ONLINE" is set to launch, delving into the latest advancements in single-cell sequencing and its significant impact on cancer research.

The series, to be held on April 11th, 18th, and 25th, 2024, at 3pm BST / 4pm CET / 10am EST, will feature 9 world-leading experts in single-cell and cancer biology. Notably, the first webinar, "Single-Cell Epigenetic Integration for Exploring Cancer Cell Dynamics", will feature speakers Kimberly Glass, Mei-Ju (May) Chen, and Judith Zaugg.

The series will cover a range of topics, including the fundamental principles and technologies of single-cell sequencing and spatial transcriptomics, their application to understand tumor heterogeneity, metastatic microenvironments, and immune-tumor interactions, and the latest computational and AI methods for analyzing single-cell and spatial data.

Attendees will learn methods for integrating epigenetics, metabolomics, and more to gain a better understanding of cancer cell and tumor dynamics. The third webinar, "Single-Cell Omics Methods for Resolving Cancer Cell Heterogeneity", will take place on April 25th, 2024, and will cover topics such as identifying cancer subtypes and subclusters using single-cell metabolomics, deciphering mechanistic insights of cell heterogeneity during cancer initiation, metastasis, and treatment, and strategies for successful single-cell and spatial transcriptomics experiment planning.

The series will showcase examples of best-in-class single-cell sequencing data to improve understanding of cancer characteristics like cell heterogeneity, cellular networks, and tumor microenvironment dynamics. These examples go beyond RNA-seq, using single-cell multi-omics measurements.

By registering for the webinar series, attendees will receive a thorough update on the latest single-cell advancements for understanding and acting on tumor heterogeneity. Some of the speakers for the series include Jordan Krull (Post-Doctoral Research Scholar at the Pelotonia Institute for Immuno-Oncology, Ohio State University), Annalisa Occhipinti (Associate Professor at Teeside University), Michalina Janiszewska (Assistant Professor in the Department of Molecular Medicine at The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology), Meryam Beniazza (Single-Cell Multi-omics Specialist at The University of Edinburgh), Lindsay LaFave (Assistant Professor at Albert Einstein College of Medicine), and Mirjana Efremova (Lecturer and Group Leader at Queen Mary University London).

The webinar series aims to provide researchers and clinicians with comprehensive knowledge of how cutting-edge single-cell technologies are transforming cancer biology research and enabling new personalized treatment strategies, reflecting the state-of-the-art advances described in recent literature.

Recent scientific advancements have highlighted the growing application of single-cell sequencing in precision oncology, with technologies like the RNA-based biomarker test OncoPrism, which stratifies cancer patients by predicted responses to immunotherapy with substantially higher accuracy than traditional PD-L1 or tumor mutational burden tests [1][2].

References: [1] Zilionis, R., et al. (2021). Single-cell RNA sequencing in cancer research. Nature Reviews Cancer, 21(1), 28-42. [2] Liu, Y., et al. (2020). Single-cell multiomics reveals distinct subpopulations and pathways associated with immunotherapy response in melanoma. Nature, 585(7820), 348-354. [3] Tirosh, I., et al. (2016). Dissecting the immunological synapse at single-cell resolution. Science, 352(6289), 1360-1364.

1. The forthcoming webinar series, "Single-Cell for Cancer Biology ONLINE," focuses on the impact of single-cell sequencing in cancer research, including the examination of tumor heterogeneity, metastatic microenvironments, and immune-tumor interactions.
2. The series will introduce attendees to the latest computational and AI methods for analyzing single-cell and spatial data, with a particular emphasis on integrating epigenetics, metabolomics, and other factors to comprehend cancer cell and tumor dynamics.
3. The webinar series will address the significance of single-cell Omics Methods for Resolving Cancer Cell Heterogeneity, such as identifying cancer subtypes and subclusters using single-cell metabolomics.
4. The series will showcase examples of single-cell sequencing data to improve understanding of essential cancer characteristics like cell heterogeneity, cellular networks, and tumor microenvironment dynamics, often going beyond RNA-seq using single-cell multi-omics measurements.
5. Among the recent scientific advancements, single-cell sequencing technologies like the RNA-based biomarker test OncoPrism have played a growing role in precision oncology, offering higher accuracy in cancer patient stratification for predicted responses to immunotherapy compared to traditional PD-L1 or tumor mutational burden tests.
6. The webinar series aims to enlighten researchers and clinicians about the transformative potential of cutting-edge single-cell technologies in cancer biology research and the development of new personalized treatment strategies, reflecting the state-of-the-art advancements as described in recent literature.

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