Potential breakthrough: Test may eradicate a genetic reason for canine blindness
In a groundbreaking development, scientists at the University of Cambridge have identified a new genetic variant responsible for Progressive Retinal Atrophy (PRA) in English Shepherds. This discovery was made possible thanks to Shola, an English Shepherd who has made a significant impact in the canine world.
Shola, known for her outstanding lineage, has recently given birth to a litter of puppies. The father of these puppies has been tested to ensure he doesn't carry the PRA gene, providing peace of mind for Shola's owners and securing the future of her offspring.
PRA is a condition that affects over 100 breeds of dogs, and it can appear in dogs as young as a few years old. If left unchecked, this condition can lead to complete blindness. In the case of Shola's puppies, the newly developed DNA test will ensure that they do not carry the PRA variant.
This DNA test, priced at £48, can show whether a dog has two, one, or no copies of the PRA variant. For English Shepherd parents, this test offers an opportunity to identify dogs with PRA early on, potentially avoiding its use in breeding.
Dogs, contrary to popular belief, are not completely color blind. They see primarily in shades of blue and yellow, a condition known as dichromacy. While they cannot distinguish reds and greens as humans do, their color range is not absent. This new DNA test is a significant step towards ensuring the health and well-being of English Shepherds and other breeds affected by PRA.
Shola's contribution to this research extends beyond her genetic material. Two of her daughters have completed mountain rescue training with Mountain Rescue England, and one of her sons is a therapy dog. One of her puppies even saved a man's life.
The research, led by Katherine Stanbury, the first author, and her University of Cambridge colleagues, involved whole genome sequencing on Shola and her brother's DNA. This comprehensive analysis allowed them to identify the specific genetic variant responsible for PRA in English Shepherds.
In the future, the team plans on screening any dog affected by a genetic eye condition for the new variant. This proactive approach could potentially end PRA in English Shepherds and other breeds, ensuring that future generations of dogs can live their lives to the fullest.
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