Study Shows Promising Results for Ketogenic Supplement in Angelman Syndrome
A recent study has shown promising results for a dietary supplement, called ketogenic medical food formulation (KF), in potentially helping children with Angelman syndrome. The trial met its primary goal of assessing the supplement's tolerability, with 13 children completing the study and accepting the powder formulation. However, a larger trial is needed to confirm its safety and efficacy, particularly in treating drug-resistant epilepsy.
The supplement, developed by Dr. Richard B. Goldstein and provided by Vitaflo, contains ketones to provide energy as in a ketogenic diet. The study found no indication that the supplement was harmful to patients. In fact, almost all participants experienced a softening in stool consistency while on KF, which was considered a considerable improvement by families. Some families also reported less food-seeking behavior, making it easier to control food intake.
The supplement did not cause any negative effects on cognition, seizure count, brain electrical activity, mobility, sleep, digestive health, or developmental stage. Half of the families chose to continue using the formula after the conclusion of the study, indicating its potential benefits. However, due to the small number of participants, the supplement's efficacy was not determined, and further research is needed.
While the initial trial shows promise for the ketogenic medical food formulation in treating Angelman syndrome, more research is needed to confirm its safety and efficacy. A larger and longer randomized placebo-controlled trial is required to fully understand the supplement's potential in managing this condition, particularly in patients with drug-resistant epilepsy.
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