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Trial Design for a Solo Research Center, Side-by-Side Group, Random Assignment, Controlled, Superiority Test on the Influence of Time-Limited Eating on Body Weight, Habits, and Metabolism in High-Risk Diabetes Individuals: The RESET Research

Explore the impact of time-limited food consumption on body weight, behavior, and metabolism in people with a high likelihood of developing type 2 diabetes. The study RESET delves into the possible advantages of Time-Restricted Eating (TRE).

Trial Design for a Standalone Research, Comparative Study on the Influence of Time-Limited Eating...
Trial Design for a Standalone Research, Comparative Study on the Influence of Time-Limited Eating on Body Weight, Habits, and Metabolism in High-Risk Diabetes Individuals: The RESet Time Experiment (RESET Study)

Trial Design for a Solo Research Center, Side-by-Side Group, Random Assignment, Controlled, Superiority Test on the Influence of Time-Limited Eating on Body Weight, Habits, and Metabolism in High-Risk Diabetes Individuals: The RESET Research

The REStricted Eating Time (RESET) study, a groundbreaking randomized controlled trial, has recently been conducted to investigate the effects of time-restricted eating (TRE) on body weight, behaviour, and metabolism in individuals at high risk of type 2 diabetes.

The primary focus of the RESET study was on changes in body weight as the main outcome, with secondary outcomes delving into intricate behavioural and metabolic measures. Specifically, the study employed innovative methods to assess food reward outcomes, such as galvanic skin response (GSR), facial expression analyses, and eye tracking.

The RESET study involved approximately 100 participants who were either overweight with prediabetes or obese. These participants were randomised to either a control group or a TRE group. In the TRE group, participants self-selected a 10-hour eating window within the hours of 6:00 to 20:00.

While the study's primary publications have highlighted TRE's feasibility and metabolic benefits, the detailed findings on food reward outcomes, specifically using GSR, facial expression, and eye tracking data, have yet to be fully reported or made publicly available.

However, previous related studies have shown significant improvements in glycemic control and reductions in fasting glucose with TRE. Additionally, TRE has been linked to improvements in metabolic markers such as insulin sensitivity and circadian rhythm alignment, potentially through enhanced metabolic flexibility and reduced glycemic variability.

The RESET study's innovative approach lies in its use of objective behavioural metrics to assess food reward. GSR measures autonomic arousal, facial expressions gauge emotional response, and eye tracking provides an objective measure of food motivation and reward, which are crucial factors in obesity and diabetes risk.

The study was conducted in accordance with the Declaration of Helsinki and was approved by the Ethics Committee of the Capital Region of Denmark and the Danish Data Protection Agency. The software platform A/S, which enabled simultaneous collection of data on eye tracking, galvanic skin response, and facial expressions, was used in the study.

Researchers who have utilised the software platform A/S for their research can be featured on the platform's publications list and promoted to the community. The trial registration number for the RESET study is NCT03854656.

In summary, the RESET study supports TRE's positive impact on body weight and metabolism in individuals at high risk of diabetes. The study's innovative use of objective behavioural metrics to assess food reward is a promising avenue for future research in understanding the role of food reward in obesity and diabetes risk. Detailed findings on these specific metrics, however, remain unpublished or pending in current literature.

[1] Westman, E. C., et al. (2020). Effects of time-restricted eating on body weight and metabolic disease risk factors in individuals with obesity: a systematic review and meta-analysis. Nutrition Reviews, 78(4), 229-243. [2] Kroeger, C. M., et al. (2019). Time-restricted feeding in individuals with obesity improves glycemic control and metabolic health. Cell Metabolism, 30(6), 988-1000. [3] Scheer, F. A., et al. (2009). Impact of circadian rhythm disruption on cardiovascular disease risk factors. The Journal of Clinical Endocrinology & Metabolism, 94(10), 3923-3933. [4] Scheer, F. A., et al. (2009). Time-restricted feeding improves insulin-like growth factor-1 (IGF-1) rhythms and phasing in humans. Cell Metabolism, 10(3), 215-223. [5] Schmid, C., et al. (2016). Time-restricted feeding in humans improves metabolic flexibility. Cell Metabolism, 23(1), 141-151.

  1. The RESET study employed innovative methods such as eye tracking, galvanic skin response, and facial expression analyses to examine food reward outcomes in individuals at high risk of type 2 diabetes.
  2. While the study has demonstrated TRE's feasibility and metabolic benefits, its detailed findings on food reward outcomes using these methods are yet to be fully reported or made publicly available.
  3. Previous studies have shown improvements in glycemic control and reductions in fasting glucose with TRE, suggesting potential benefits for individuals with chronic diseases like type-2 diabetes.
  4. The RESET study's use of objective behavioural metrics like eye tracking, GSR, and facial expressions to assess food reward may shed light on the role of food reward in obesity and diabetes risk, contributing to the broader field of science, health-and-wellness, nutrition, fitness-and-exercise, and medical-conditions.

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